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FLASH GENE
Symbol MOV10 contributors: mct/shn - updated : 29-09-2015
HGNC name Mov10, Moloney leukemia virus 10, homolog (mouse)
HGNC id 7200
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region may be responsible for the formation of MOV10–TERT complex (Nakano 2009)
  • NP (ATP) binding domain
  • DEAG Box
  • HOMOLOGY
    interspecies ortholog to Mov10, Mus musculus
    ortholog to Mov10, Rattus norvegicus
    homolog to drosophila Armitage
    ortholog to MOV10, Pan troglodytes
    Homologene
    FAMILY
  • RNA helicase superfamily-2
  • argonaute-associated proteins family
  • SDE3 subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,chromatin/chromosome
    text
  • both APOBEC3G and MOV10 have been found to co-localize with AGO1 and AGO2 in P-bodies and stress granules
  • MOV10 and APOBEC3G (A3G) localize to cytoplasmic granules called processing bodies (P bodies)
  • basic FUNCTION
  • may be an helicase with an important function in development and in control of cell proliferation
  • required to mediate microRNA-guided mRNA cleavage
  • may play a role in RNA-directed transcription
  • involved in the progression of telomerase-catalyzing reaction via the interaction of telomerase protein and telomere DNA
  • may have some role(s) in normal cells and it may regulate telomerase activity to bind to TERT and telomere DNA
  • preferentially expressed in telomerase-positive organs and the cancer cells, and physically and functionally associated with TERT and telomere
  • has a broad antiretroviral activity that can target a wide range of retroviruses, and it could be actively involved in host defense against retroviral infection
  • involved in transcriptional silencing by PcG complexes
  • can potently inhibit HIV-1 replication at multiple stages
  • may be potentially a component of a cellular pathway or process that selectively regulates the replication of endogenous retroelements in somatic cells
  • putative RNA helicase and component of the RNA-induced silencing complex (RISC), inhibiting retrovirus replication
  • may represent an ancient and innate form of immunity against both infective viruses and endogenous retroelements
  • MOV10 contributes to the cellular control of LINE-1 replication
  • MOV10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide
    PHYSIOLOGICAL PROCESS development
    text a putative RNA helicase
    PATHWAY
    metabolism
    signaling
    a component
  • Polycomb-repressive complex 1, PRC1
  • INTERACTION
    DNA chromatin in an RNA-dependent manner
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • Polycomb-repressive complex 1, PRC1
  • APOBEC3G binds to a domain at the C terminus in MOV10, where it competitively inhibits the binding of AGO2 to that same domain
  • MOV10 functions in UPF1-mediated mRNA degradation as an RNA clearance factor to resolve structures and displace proteins from 3prime UTRs
  • FMR1 associates with the RNA helicase MOV10, also associated with the microRNA pathway, in an RNA-dependent manner and facilitates MOV10 association with RNAs in brain and cells, suggesting a cooperative interaction
  • RNA helicase MOV10 plays a role in WNT5A synthesis and secretion
  • HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev
  • cell & other
    REGULATION
    repressed by acyclic AMP,retinsic acid
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS