Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MAPKAP1 contributors: mct/npt/pgu - updated : 13-02-2013
HGNC name mitogen-activated protein kinase associated protein 1
HGNC id 18752
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Raf-like Ras-binding domain (RBD) able to bind activated H-and K-Ras and a pleckstrin homology (PH) domain involved in lipid and membrane binding by MAPKAP1
  • a nuclear localization signal
  • two bipartite nuclear localization signals
  • a peroxisomal targeting signal
  • a PEST motif for rapid protein degradation
  • C-terminus having the pleckstrin homology (PH) domain foldand omparison with known PH-domain structures suggests a putative binding site for phosphoinositides
  • HOMOLOGY
    interspecies homolog to murine Mapkap1 (97.1pc)
    homolog to rattus Mapkap1 (96.9pc)
    ortholog to S.cerevisiae Avo1
    Homologene
    FAMILY
  • SIN1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    basic FUNCTION
  • regulating MEKK2 dimerization and activation by forming a complex with inactive and non-phosphorylated MEKK2
  • maintaining CRTC2 complex integrity and regulating Akt phosphorylation and substrates specificity
  • may act as scaffold molecules in the regulation of signaling by JNK
  • scaffold protein that organizes antiapoptotic responses in stressed cells
  • plays an important role in the SAPK signaling pathway by binding to both ATF 2 and MAPK14
  • may contribute to ATF2 signaling specificity by acting as a nuclear scaffold (Makino 2006)
  • regulates B cell development
  • mediates SGK1 protein interaction with CRTC2 protein complex and is required for selective activation of the epithelial sodium channel
  • serves as a selectivity adaptor for the recruitment of CRTC2 targets
  • plays key roles in the regulation of mitogen-activated protein kinase (MAPK) and MTOR signaling
  • MAPKAP1 and CRTC2 are dispensable for the development and activation of T cells but play a role in natural T-regulatory (nTreg) cells differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    ras pathway
    a component
  • component of CRTC2, a protein kinase complex involved in AKT phosphorylation and cell signaling
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to MAPK
  • binding to JNK
  • interaction wth RICTOR (with Rictor are key components of mTORC2 and play an essential role in Akt phosphorylation and signaling)
  • PCBP2, its binding partner, provides for the selective expression of cell survival factors through posttranslational events
  • binds directly to both ATF2 and MAZPK14
  • Ras-inhibitor
  • MAPKAP1/CRTC2-AKT2 signaling axis is a key regulator of FOXO1 transcriptional activity in B cells
  • serves as a selectivity adaptor for the recruitment of CRTC2 targets
  • interacts with MAPKAP1, a component of the MTOR complex 2 (CRTC2), and this interaction is important both in the context of MTOR signaling
  • specific domains of MTOR, RICTOR, or MAPKAP1 interacted with the internal domain (AA. 221-402) of NBN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS