SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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basic FUNCTION
| involved in recruiting unphosphorylated SMAD2/SMAD3 proteins to the TGF beta receptor by controlling SMAD subcellular localization and by interacting with the TGFB receptor complex |
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playing an important functional role downstream of Rab5-regulated endosomal trafficking |
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facilitates TGFbeta and activin/nodal signaling by recruiting and presenting Smad2/3 to the receptor complex |
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ZFYVE9-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods |
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playing a role in presenting R-Smads to the receptor for phosphorylation |
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early endosomal protein, playing a key role in TGFB signalling |
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is dispensable for functional TGFB-mediated signaling |
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regulator of epithelial cell phenotype, with reduced expression during TGFB1-mediated epithelial-to-mesenchymal transition |
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RNF11 and ZFYVE9 participate structurally and functionally in the ESCRT-dependent lysosomal degradation of receptors |
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is an early endosomal protein facilitating TGFB1 signaling cascade |