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FLASH GENE
Symbol KREMEN1 contributors: mct - updated : 05-10-2010
HGNC name kringle containing transmembrane protein 1
HGNC id 17550
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a kringle domain
  • a WSC, a CUB domain
  • six glycosylation sites in the extracellular region
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Kremen
    homolog to rattus Kremen
    homolog to Xenopus Xl.12084
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • DKK receptor, cooperating with DKK1 to block WNT, beta catenin signaling pathway
  • playing a role for in proper development of thymic epithelium
  • not universally required for DKK1 function
  • inducing exocytosis, cell cell interaction
  • functions as the gatekeeper of Wnt signalling in development and pathology )
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , cell to cell transport , exocytosis transport , electron transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of a ternary complex with DKK1 and the lipoprotein related protein - (LRP6)
  • components of a membrane complex modulating canonical WNT signaling through LRP6
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to LRP6, KREMEN2
  • with KREMEN2, identified to be the high-affinity receptors for Dickkopf (Dkk), the inhibitor of Wnt/beta-catenin signalling
  • functional interaction of Kremen proteins with DKK1 as negative regulators of Wnt/beta-catenin signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to schizophrenia in the Japanese
  • Variant & Polymorphism other
  • a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Krm double mutants show enhanced Wnt signaling accompanied by ectopic postaxial forelimb digits and expanded apical ectodermal ridges