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FLASH GENE
Symbol KCNE4 contributors: mct - updated : 08-06-2011
HGNC name potassium voltage-gated channel, Isk-related family, member 4
HGNC id 6244
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a glycosylation site
  • a transmembrane domain
  • a cytoplasmic domain of KCNE4 that is necessary for its inhibition of KCNQ1
  • a tetraleucine motif in the juxtamembrane region of the C terminus , interacting with KCNQ1
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies ortholog to murine Kcne4
    intraspecies homolog to KCNE1
    Homologene
    FAMILY potassium channel E family
    CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • ancillary protein modulating the gating kinetics and enhance stability of the multimeric complex
  • inhibiting potassium current by inhibiting KCNQ1 activation
  • may act as a subunit of KCNJ2 channel to modulate the potassium channel function
  • functions as an inhibitory KCNA3 partner in leukocytes
  • KCNE4 association might play a crucial role in controlling immunological responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
  • potassium channel alpha subunit, like KCNQ1
  • directly associates with KCNQ1, and can co-associate together with KCNE1 in the same KCNQ1 complex to form a 'triple subunit' complex (KCNE1-KCNQ1-KCNE4)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may coassemble with KCNQ subunits
  • has a dramatic inhibitory effect on KCNQ1 that differs substantially from the activating effects of KCNE1 and KCNE3
  • associates with KCNA3 in the ER and decreases the number of KCNA3 channels at the cell surface, which diminishes cell excitability
  • modulate KCND current activation, inactivation and recovery from inactivation, in a KCNIP2-dependent manner
  • can biochemically interact with CALM1 and this interaction is Ca(2+)-dependent and requires a tetraleucine motif in the juxtamembrane region of the KCNE4 C terminus
  • interaction between KCNE4 and CALM1 could be involved in the modulation of KCNQ1 by KCNE4
  • CALM1-KCNE4 interactions might constitute part of a feedback loop for regulating intracellular Ca2+
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS