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FLASH GENE
Symbol ITM2C contributors: mct - updated : 10-04-2012
HGNC name integral membrane protein 2C
HGNC id 6175
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal anchor transmembrane domain
  • N-glycosylation site
  • a BRICHOS domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Itm2c
    homolog to rattus Rn.8450
    homolog to Xenopus Xl.18806
    Homologene
    FAMILY ITM2 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    text type II membrane protein
    basic FUNCTION
  • inhibits the various processing of APP by blocking the access of alpha- and beta-secretases to APP
  • unlike ITM2B, ITM2C is a poor gamma-cleavage inhibitor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BACE1 and BRI3 co-localize and interact with each other via the cytosolic tail of BACE1
  • interacts with APP and serves as an endogenous negative regulator of Abeta production
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS