Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IRAK3 contributors: npt/pgu - updated : 09-06-2016
HGNC name interleukin-1 receptor-associated kinase 3
HGNC id 17020
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal DEATH domain
  • tyrosine kinase catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Irak3
    Homologene
    FAMILY
  • protein kinase superfamily
  • IRAK family
  • Ser/Thr family of protein kinases
  • Pelle subfamily
  • CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • involved in lipopolysaccharide signal transduction, negative regulator
  • TOLL-like receptor (TLR) signaling, preventing dissociation of IRAK1 and IRAK4 from MYD88 and the formation of IRAK/TRAF6 complexes
  • involved in the pathogenesis of early-onset persistent asthma
  • play a pivotal role in the process of 'endotoxin tolerance' in human monocytes
  • initiate a cascade of signaling events eventually leading to induction of inflammatory target gene expression
  • IRAK3 is an important target for CASP6 (neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IRAK3)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    contributing to endotoxin tolerance and innate immunity homeostasis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MYD88, IRAK1, IRAK4
  • negative regulator of the Toll-like receptor/IL-1R pathways, master regulator of NF- kappa B and inflammation
  • IRAK2 plays a key role in the TLR9-mediated transcriptional regulation of IRAK3 expression by sustaining activation of PKD1 and NFKB1
  • cell & other
    REGULATION
    induced by in the presence of a PI3K inhibitor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    IRAK3 were down-regulated in HCC (hepatocellular carcinoma)cell lines through promoter methylation
    Susceptibility to early-onset persistent asthma
    Variant & Polymorphism
    Candidate gene
    Marker
  • detection of IRAK3 methylation would be helpful in the prediction of patients’ survival as well as the follow-up of patients in hepatocellular carcinoma
  • dysregulated levels of the IRAK3 may be involved in sepsis pathophysiology and may be utilized as potential diagnostic biomarkers
  • Therapy target
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    IRAK3 were down-regulated in HCC (hepatocellular carcinoma)cell lines through promoter methylation
    Susceptibility to early-onset persistent asthma
    Variant & Polymorphism
    Candidate gene
    Marker
  • detection of IRAK3 methylation would be helpful in the prediction of patients’ survival as well as the follow-up of patients in hepatocellular carcinoma
  • dysregulated levels of the IRAK3 may be involved in sepsis pathophysiology and may be utilized as potential diagnostic biomarkers
  • Therapy target
    ANIMAL & CELL MODELS