Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol INPP5E contributors: mct - updated : 03-05-2016
HGNC name inositol polyphosphate-5-phosphatase, 72kDa
HGNC id 21474
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal proline rich domain
  • a central 5-phosphatase domain
  • inositol polyphosphate phosphatase catalytic domain
  • a C-terminal CAAX motif
  • mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Inpp5e
    homolog to rattus Rn.11175
    homolog to xenopus Xl.6709
    homolog to C.elegans Y71G12B.24
    Homologene
    FAMILY
  • inositol-1,4,5-trisphosphate 5- phosphatase type IV family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • predominantly located to the Golgi
  • localizes predominantly to the primary cilium during interphase
  • basic FUNCTION
  • cleaving the N terminal transit peptide from mitochondrial protein precursors
  • may hydrolyzes phosphatidylinositol 3,4, 5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby may regulate Golgi-vesicular trafficking
  • with INPP5D and INPP5K, implicated in negatively regulating insulin signalling and glucose homoeostasis in specific tissues
  • regulate macrophage phagocytosis
  • plays an essential role in the primary cilium by controlling ciliary growth factor and PI3K signaling and stability
  • functions to stabilize the normal structure and number of primary cilia in quiescent cells stimulated by growth factors
  • regulates cilia stability
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • alpha MPP and beta MPP
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactions of INPP5E with several ciliary and centrosomal proteins, including a recently identified ciliopathy protein centrosomal protein 164 (CEP164)
  • is a novel prenyl-dependent cargo of PDE6D
  • MKS1 functions in the transition zone at the base of the cilium to regulate ciliary INPP5E content, through an ARL13B-dependent mechanism
  • ARL13B regulates IFT-A-mediated retrograde protein trafficking within cilia through its interaction with INPP5E
  • cell & other
  • is targeted to the primary cilium through a motif near the C terminus and PDE6D (PDE6D)-dependent mechanisms
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MORM , JBTS1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS