SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleoplasm,nuclear bodies
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| intracellular,nucleus,chromatin/chromosome,centromere
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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| intracellular,nucleus,nucleolus
|
text
| localized to metaphase chromosomes and to the mitotic spindle and equatorial cortex at anaphase and also in the cleavage furrow |
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cytoplasmic face of the plasma membrane |
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as mitosis progresses, with Survivin, Aurora B, CDCA8 dynamically colocalize to mitotic structures |
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accumulate in the interphase nucleolus in an RNA polymerase I-dependent manner (Wong 2007) |
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unlike wild-type INCENP, truncated INCENP localizes to pre-anaphase spindle microtubules |
basic FUNCTION
| required for chromosome segregation and the onset of cytokinesis during mitosis |
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moves from the central spindle to the furrow of a dividing cell by a KIF12-dependent pathway (once INCENP reaches the equatorial cortex, it associates with the actin cytoskeleton where it then concentrates toward the end of cytokinesis) (Chen 2007) |
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playing a role in the regulation of sister chromatid separation in mitosis (loss of INCENP is accompanied by loss of cohesion) |
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essential for central spindle and midbody localization of chromosomal passenger complex |
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dual recognition of chromatin and microtubules by INCENP is important for mitotic progression |
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plays a catalytic role in AURKB autophosphorylation (Yang 2009) |
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modulates AURKB kinase activity and chromosomal passenger complex (CPC) localization, which is essential for timely mitotic progression |