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FLASH GENE
Symbol IL22RA1 contributors: mct - updated : 09-04-2019
HGNC name interleukin 22 receptor, alpha 1
HGNC id 13700
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • an extracellular domain
  • two fibronectin type III (FnIII) domains
  • glycosylation sites
  • a transmembrane domain
  • an intracellular domain with four potential Stat3 recruitement motifs (YXXQ)
  • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Il22r
    intraspecies homolog to IL22RA2
    Homologene
    FAMILY
  • type II cytokine receptor family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in the recruitment of Stat proteins
  • the role of the IL22/IL22RA1 axis in cancer is complex and context-specific
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of the membranar receptor of IL22
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to IL22, Stat3, Jak1, CRF2-4, IL22RA, IL22RA1 and IL-20RB
  • IL22 secreted by decidual stromal cells (DSCs) and decidual natural killer (dNK) cells might promote the survival of trophoblasts and participate in the maintenance of pregnancy by binding to the IL22RA1
  • increased expression of IL22RA1 promotes keratinocyte proliferation and pro-inflammatory cytokine production during UVB-induced skin inflammation, suggesting that UVB facilitates skin inflammation by increasing the responsiveness of keratinocytes to IL22
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to preeclampsia (PE)
  • Variant & Polymorphism other IL22RA1 rs3795299 may be associated with the development of preeclampsia (PE)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS