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FLASH GENE
Symbol IL18RAP contributors: mct - updated : 06-06-2008
HGNC name interleukin 18 receptor accessory protein
HGNC id 5989
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 14-amino acid signal peptide
  • a 342-amino acid extracellular (Ig superfamily-like) segment
  • three Ig like domains
  • three glycosylation potential sites
  • single transmembrane region
  • a 222-amino acid cytoplasmic domain
    • mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Il18rap
    Homologene
    FAMILY
  • interleukin-1 receptor (IL-1R) family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • required for induction of NFkappaB activity and for activation of c-Jun N-terminal kinase
  • pleiotropic cytokine involved in the regulation of both innate and adaptive immunity and playing a key role in the autoimmune, inflammatory and infectious diseases
  • essential for IL-18 signal transduction and ligand binding affinity to IL-18Ralpha receptor chain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text Th1 immune response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterodimerizing with IL18R1
  • component of IL18 receptor
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by IFN-alpha,IL-12
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Crohn's disease and ulcerative colitis
    Variant & Polymorphism SNP increasing the risk of Crohn's disease and ulcerative colitis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS