basic FUNCTION
| involved in cell-growth control and immune response |
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component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals |
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implicated in cell-to-cell homotypic adhesion and antiproliferative signaling in leukocytes and endothelial cells |
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could inhibit the activity of extracellular signal-regulated kinase, enhance the transcriptional activity of TP53 and stabilize the TP53 protein by inhibiting TP53 phosphorylation on Thr55 |
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essential mediator of interferon-g-induced antiproliferation |
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IFITM1, IFITM2, IFITM3 mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus |
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activated CTNNB signaling pathway including IFITM1 might play an important role in a subset of Peutz-Jeghers syndrome polyps |
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act as antiviral restriction factor |
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IFITM1, IFITM2, IFITM3 are important components of the innate immune system to restrict HIV-1 infection |
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IFIT1 and IFITM1 serve as important molecules to restrict HCV infection, and they may have implications in the development of therapeutic modalities |
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IFITM1, IFITM2, IFITM3 are potentially involved in the differentiation and cell proliferation during heart development |