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FLASH GENE
Symbol IFITM1 contributors: mct - updated : 17-03-2012
HGNC name interferon induced transmembrane protein 1 (9-27)
HGNC id 5412
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two transmembrane domains
mono polymer complex
HOMOLOGY
interspecies homolog to C.elegans H06H21.7
Homologene
FAMILY
  • IFN-induced transmembrane protein family
  • IFITM family
  • CATEGORY regulatory , antigen , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in cell-growth control and immune response
  • component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals
  • implicated in cell-to-cell homotypic adhesion and antiproliferative signaling in leukocytes and endothelial cells
  • could inhibit the activity of extracellular signal-regulated kinase, enhance the transcriptional activity of TP53 and stabilize the TP53 protein by inhibiting TP53 phosphorylation on Thr55
  • essential mediator of interferon-g-induced antiproliferation
  • IFITM1, IFITM2, IFITM3 mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
  • activated CTNNB signaling pathway including IFITM1 might play an important role in a subset of Peutz-Jeghers syndrome polyps
  • act as antiviral restriction factor
  • IFITM1, IFITM2, IFITM3 are important components of the innate immune system to restrict HIV-1 infection
  • IFIT1 and IFITM1 serve as important molecules to restrict HCV infection, and they may have implications in the development of therapeutic modalities
  • IFITM1, IFITM2, IFITM3 are potentially involved in the differentiation and cell proliferation during heart development
  • CELLULAR PROCESS cell life, proliferation/growth
    cell communication
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • does not have receptor activity, it does form a complex with CD81–CD19–CD21 and amplifies signal transduction in B lymphocytes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • localized in caveolae of the plasma membrane and could interact with CAV1 (interaction between IFITM1 and CAV1 could enhance the inhibitory effect of CAV1 on ERK activation)
  • cell & other
    REGULATION
    induced by interferon alpha/beta(IFNA/IFNB), interferon gamma(IFNG),X-ray,angiotensin 2 (A-II)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in chronic myeloid leukemia with good prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS