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FLASH GENE
Symbol SF3A2 contributors: - updated : 24-05-2006
HGNC name splicing factor 3a, subunit 2, 66kDa
HGNC id 10766
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a proline rich short consensus repeats
  • a single zinc finger domain
  • mono polymer heteromer , trimer , complex
    HOMOLOGY
    interspecies homolog to yeast splicing factor PRP11
    ortholog to yeast S.cerevisiae PRP11
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • converting the U2 snRNP to its active form
  • can induce neurite extension, and having functions in the regulation of cell morphology
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • spliceosome component of "a" complex of three subunits (SF3A1, SF3A2, SF3A3) required for the binding of U2 to the branch point in pre-mRNA sequence
  • INTERACTION
    DNA
    RNA
    small molecule
    protein binds to beta-tubulin, and also to microtubules, with high affinity (it is a novel microtubule-associated protein)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS