basic FUNCTION
| suppressing HES1 from repressing transcription |
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transcriptional repressor of genes that require a BHLH protein for their transcription |
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may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 |
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promoting, instead of inhibiting, neuronal and myogenic differentiation and probably through antagonizing the HES1 and HES5 functions |
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in the inner ear, might be involved in the differentiation of hair cells and promotes neuronal differentiation in the neural plate, the retina and in the cortex |
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basic helix-loop-helix transcription factor that functions in the differentiation of pluripotent progenitor cells and during tumorigenesis |
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estrogen-regulated gene in breast cancer cells |
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regulate proliferating cell fate in development and is known to be expressed in developing muscle |
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novel role in actin cytoskeletal dynamics in post mitotic myoblasts |
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important role for HES6 in supporting survival of glioma cells, as evidenced by reduction of cancer cell proliferation and migration after HES6 silencing |
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is important for glioma cell proliferation and migration, and may have a role in angiogenesis |
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is likely involved in the regulation of neuroblast differentiation during adult neurogenesis, but does not influence integration into mature neurons |