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FLASH GENE
Symbol GPRC6A contributors: mct - updated : 08-04-2015
HGNC name G protein-coupled receptor, family C, group 6, member A
HGNC id 18510
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a seven-transmembrane (7TM) domain
  • an unusually long amino-terminal domain (ATD) of 590 amino acids
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 3 family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cation-, calcimimetic-, and osteocalcin-sensing receptor
  • may mediate extracellular calcium-sensing responses in osteoblasts
  • may act as a regulatory component of the urea cycle
  • may function as the receptor component of a novel cellular transmitter system in mammals
  • cation-, calcimimetic-, and osteocalcin-sensing receptor and a candidate for mediating extracellular calcium-sensing responses in osteoblasts and possibly other tissues
  • directly participates in the regulation of osteoblast-mediated bone mineralization and may mediate the anabolic effects of extracellular amino acids, osteocalcin, and divalent cations in bone
  • calcium and amino acid sensing GPCR, transducing the non-genomic effects of testosterone and other steroid
  • is functionally important in regulating non-genomic effects of androgens in multiple tissues
  • may function as an anabolic receptor coordinating the responses of multiple tissues to changes in nutrients and other factors
  • sensing properties of GPRC6A, along with its responsiveness to anabolic steroids, may provide a means to coordinate nutritional and hormonal anabolic signals in multiple organs
  • role for GPRC6A in L-arginine-induced insulin release and glucose metabolism under normal physiological conditions
  • serves as a sensor and mediator of the rapid action of testosterone in epidermal keratinocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • speculated to form covalently linked dimers through cysteine disulfide linkage in the extracellular amino-terminal domain
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a candidate for mediating the response to BGLAP in the bone-pancreas endocrine loop regulating insulin signaling
  • BGLAP regulates beta-cell replication in a cyclin D1-dependent manner by signaling through the GPRC6A receptor expressed in these cells
  • testosterone stimulates DUOX1 activity through GPRC6A in skin keratinocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer cell
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate for mediating extracellular calcium-sensing responses in osteoblasts and possibly other tissues
  • GPRC6A is a candidate for mediating the response to BGLAP in the bone-pancreas endocrine loop regulating insulin signaling
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    molecular target for regulating prostate growth and cancer progression
    ANIMAL & CELL MODELS
  • GPRC6A null (GPRC6A(-/-) mice exhibit multiple metabolic abnormalities including osteopenia
  • loss of GPRC6A retarded the progress and improved survival of a mouse model of prostate cancer
  • Gprc6A-null mice exhibit a mild metabolic syndrome phenotype characterized by hyperglycemia, decreased serum insulin levels, glucose intolerance, and insulin resistance