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FLASH GENE
Symbol GLYAT contributors: mct/npt - updated : 29-09-2015
HGNC name glycine-N-acyltransferase
HGNC id 13734
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • glycine N-acyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • glycine-N-acyltransferase protein conjugating glycine with acyl-CoA substrates in the mitochondria
  • having substantial capacity towards its preferred substrates, with indisputable therapeutic impact
  • is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA and in regulating glucose metabolism and energy metabolism
  • essential to glucose metabolism and energy metabolism, suggesting the gene dual role in both bone development and muscle growth
  • importance of GLYAT gene in co-regulation of bone phenotypes and body lean mass
  • essential to glucose metabolism and energy metabolism, suggesting the gene dual role in both bone development and muscle growth
  • is a phase II metabolic detoxification enzyme for exogenous (xenobiotic) and endogenous carboxylic acids
  • catalyzes the formation of hippurate (N-benzoylglycine) from the corresponding glycine and benzoyl-CoA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS detoxification
    text detoxification of endogenous and xenobiotic acyl-CoA's.
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    is associated to hyperglycemia diseases
    Susceptibility to variation of bone size and body lean mass
    Variant & Polymorphism SNP
  • three SNPs were also associated with variation of bone size and body lean mass
  • SNP variations in GLYAT gene influence the kinetic properties of the enzyme, and may explain some of the inter-individual variation in glycine conjugation capacity, which is relevant to the metabolism of xenobiotics such as aspirin and the industrial solvent xylene
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS