basic FUNCTION
| acts globally to specify positional identity along the anterior/posterior axis  |
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plays a unique role in patterning both mesodermal and neural tissues  |
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controlling the numbers of retinal ganglion cells, as well as amacrine and photoreceptor cells, that form during development |
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play important roles in the development of the olfactory system, retina, and pancreas as well as in anterior–posterior patterning of the axial skeleton |
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facilitate temporal progression of neurogenesis in the developing spinal cord  |
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expression of PCSK5 and GDF11, which plays a crucial role in the organogenesis of the hindgut, was disturbed in the hindgut region when retinoid-mediated signaling was disrupted  |
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GDF11, ACTB and FST are crucial components of a circuit that controls both total cell number and the ratio of neuronal versus glial cells in in this system  |