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FLASH GENE

Symbol

GABRP

contributors: - updated : 07-06-2006

HGNC name	gamma-aminobutyric acid (GABA) A receptor, pi
HGNC id	4089

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

basic FUNCTION	involved in alteration of chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system
	having a function related to tissue contractility

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

binding of this pi subunit with other gaba(a) receptor subunits

INTERACTION

DNA

RNA

small molecule

protein

binding with other gaba(a) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to schizophrenia

Variant & Polymorphism SNP	increasing the risk of schizophrenia

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS