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FLASH GENE
Symbol FOLH1 contributors: mct/npt - updated : 25-02-2009
HGNC name folate hydrolase (prostate-specific membrane antigen) 1
HGNC id 3788
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal membrane spanning region
  • a catalytic region of 313AA with two catalytic zinc atoms
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to porcine FGCP
    homolog to rattus Naaladase
    Homologene
    FAMILY
  • glutamate carboxypeptidase family
  • peptidase family M28
  • CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text type II transmembrane protein
    basic FUNCTION
  • folate hydrolase and NAALAdase activity
  • involved in conversion of the major neurotransmitter (NAAG) to NAA and free glutamate
  • acting as a glutamate carboxypeptidase (Giusti 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in metastatic prostatic carcinoma
    Susceptibility
  • to cardiovascular disease (CVD)
  • to abdominal aortic aneurysm (Giusti 2008)
  • Variant & Polymorphism other 1561C-->T polymorphism may affect the predisposition to CVD.
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS