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FLASH GENE
Symbol PTPRE contributors: mct - updated : 28-10-2015
HGNC name protein tyrosine phosphatase, receptor type, E
HGNC id 9669
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two protein-tyrosine phosphatase domains
  • a unique 132-residue long C-terminal end with no known motifs or homology to other characterized proteins
  • HOMOLOGY
    Homologene
    FAMILY protein-tyrosine phosphatase family, receptor class 4 subfamily
    CATEGORY receptor membrane G phosphatase
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus
    basic FUNCTION
  • playing a regulatory role in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels
  • inhibiting the mitogen-activated protein kinase cascade through the extracellular signal-regulated kinase 1 and 2 pathway
  • negatively regulates potentially the development of atherosclerosis by activating SRC
  • negatively regulates FCER1A-mediated signalling pathways and thus constitutes a novel target for ameliorating allergic conditions
  • negatively regulates PDGFRB-mediated signaling pathways that are crucial for the pathogenesis of atherosclerosis, and may be involved in diabetes-accelerated atherosclerosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • biomarker for thyroid cancer exhibiting differences in the correlation coefficients between benign and malignant samples that indicate its discriminatory power
  • Therapy target
    ANIMAL & CELL MODELS