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FLASH GENE
Symbol EIF2B2 contributors: mlc - updated : 19-12-2007
HGNC name eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
HGNC id 3258
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Eif2b2
homolog to chimpanzee eif2b2
homolog to rattus eif2b2
homolog to chicken eif2b2
Homologene
FAMILY EIF2B alpha/beta/delta subunits family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • eukaryotic initiation factor-2B (EIF2B) is a GTP exchange factor essential for protein synthesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) VWM2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS