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FLASH GENE
Symbol AP2B1 contributors: - updated : 20-05-2006
HGNC name adaptor-related protein complex 2, beta 1 subunit
HGNC id 563
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two globular adaptin domains interconnected by a variable and potentially flexible stalk domain
  • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY adaptor complexes large subunits complex
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text cytoplasmic face of clathrin coated vesicles
    basic FUNCTION
  • potentially mediating rapid internalization
  • playing a major role in clathrin coat formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of assembly protein complex AP-2, clathrin coat assembly complex linking clathrin to receptors in coated pits and vesicles
  • heterotetramer composed of two large chains (alpha and beta),a medium chain (AP50) and a small chain (AP17)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with both cargo and clathrin
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS