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FLASH GENE
Symbol DGKD contributors: mct - updated : 02-09-2014
HGNC name diacylglycerol kinase, delta 130kDa
HGNC id 2851
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal pleckstrin homology domain (PH)
  • two zinc-dependent phorbol-ester and DAG binding domains
  • one PH domain
  • one sterile alpha motif (SAM) domain, binding zinc at multiple sites, and driving the organization of the DGKD SAM into large sheets of polymers
    • mono polymer homomer , octamer
    HOMOLOGY
    interspecies homolog to murine Dgkd
    Homologene
    FAMILY eukaryotic diacylglycerol kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • converting diacylglycerol to phosphatidic acid
  • negatively regulating ER-to-Golgi traffic by selectively inhibiting the formation of ER export sites without significantly affecting retrograde transport
  • DGKdelta regulates EGFR by modulating PKC signaling
  • involved in central nervous system development and function
  • specifically regulates AKT1 signaling downstream of potentially oncogenic RTKs
  • markedly increases lipid synthesis, at least in part as a result of promoting the de novo synthesis of fatty acids
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component heterodimerizing with DGK
    INTERACTION
    DNA
    RNA
    small molecule
  • zinc may play an important role in the assembly and physiology of the DGKD isozyme
    • protein
  • DGKD and PRKCA modulate the levels of ubiquitinated EGFR through AKT1 and USP8
    • cell & other
    REGULATION
    induced by phorboester (isoform 2)
    Other suppressed by phorboester (isoform 1)
    polymerization of DGKD regulates the activity of the enzyme by sequestering DGKD in an inactive cellular location
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in epilepsy
    tumoral       loss of function
    reduced proliferation and migration and enhanced apoptosis of cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS