basic FUNCTION
| mediating the release of the spliced mrna from spliceosomes |
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important modulator of 47S rRNA transcription |
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cell cycle-regulated nucleolar protein that associates with ribosomal DNA (rDNA) loci, where it interacts with the RNA Pol I transcription factor upstream binding factor (UBF) |
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crucial player in establishing rRNA synthesis rates in the face of RAS or ARF signals, adjusting ribosome biogenesis to match the appropriate growth or antigrowth signals |
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double-stranded RNA (dsRNA) sensor in myeloid dendritic cells |