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FLASH GENE
Symbol DHX33 contributors: mct - updated : 31-10-2015
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 33
HGNC id 16718
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one S1 motif
  • DEAD/H box (Asp - Glu - Ala - Asp/His)
  • C terminal RNA helicase domain
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEAH subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • mediating the release of the spliced mrna from spliceosomes
  • important modulator of 47S rRNA transcription
  • cell cycle-regulated nucleolar protein that associates with ribosomal DNA (rDNA) loci, where it interacts with the RNA Pol I transcription factor upstream binding factor (UBF)
  • crucial player in establishing rRNA synthesis rates in the face of RAS or ARF signals, adjusting ribosome biogenesis to match the appropriate growth or antigrowth signals
  • double-stranded RNA (dsRNA) sensor in myeloid dendritic cells
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, recombination
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    APT
    protein
  • is a cytosolic RNA sensor that activates the NLRP3 inflammasome
  • RNA helicase DHX33 binds to cytosolic dsRNAs to trigger NLRP3 inflammasome activation
  • interaction between the helicase DHX33 and MAVS (interaction between DHX33 and MAVS is mediated by the HELICc region of DHX33 and the C-terminal domain of MAVS)
  • ubiquitination of DHX33 by TRIM33 is lysine 63 specific and is required for the formation of the DHX33-NLRP3 inflammasome complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS