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FLASH GENE
Symbol DDX28 contributors: mct - updated : 28-12-2017
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
HGNC id 17330
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal DEAD box (Asp-Glu-Ala-Asp/His) with three basic domains and its RNA binding ability were essential for nucleolar localization as well as transcription-inhibition-dependent localization to nuclear subcompartments
  • a SPRY domain,a second DEAD box and a C terminal helicase domain
  • HOMOLOGY
    Homologene
    FAMILY DEAD-like helicase superfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in nucleo-cytoplasmic shuttling dependent on the availability of nascent RNA
  • is a RNA granule component essential for the biogenesis of the mitoribosome large subunit (mt-LSU)
  • is essential during the early stages of mitoribosome mt-LSU biogenesis, a process that takes place mainly near the mitochondrial nucleoids, in the compartment defined by the RNA granules
  • DHX30 and DDX28 and FASTKD2 are required for mitochondrial ribosome biogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    ATP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS