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FLASH GENE
Symbol DCD contributors: - updated : 06-01-2006
HGNC name dermcidin
HGNC id 14669
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to lacritin
Homologene
FAMILY
CATEGORY regulatory , secretory , protooncogene
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • broad spectrum, antimicrobial peptide, playing a role in the regulation of human skin flora
  • playing a role in tumorigenesis by means of enhancing cell growth and survival in a subset of breast carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text innate immunity
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Mn2+ binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in invasive breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS