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FLASH GENE
Symbol COTL1 contributors: mct - updated : 28-08-2010
HGNC name coactosin-like 1 (Dictyostelium)
HGNC id 18304
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • actin depolymerization factor/cofilin-like domain
    • HOMOLOGY
    interspecies ortholog to murine Cotl1
    intraspecies homolog to Dictyostelium protein stimulating autonomous replication
    Homologene
    FAMILY
  • actin-binding proteins ADF family
  • coactosin subfamily
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microfilament
    basic FUNCTION
  • regulating the actin cytoskeleton
  • in stimulated cells, functioning in a complex together with 5-lipoxygenase (5LO) and membranes, increasing the capacity of 5LO for leukotriene biosynthesis
  • playing a role as a chaperoning scaffold factor, influencing both the stability and the activity of ALOX5
  • binds to and chaperones ALOX5 in the cytosol of neutrophils
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    leukotriene
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to F-actin in a calcium-independent manner
    • and 5 lipoxygenase exclusively from each other
  • binds ALOX5 and promotes leukotrienes formation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autoimmune disorders
    Variant & Polymorphism other c.-1124G>T and c. 484G>A polymorphisms of the COTL1 gene might be associated with the genetic susceptibility of autoimmune disorders
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmune 
    COTL1/ALOX5 as therapy to reduce leukotriene formation in the cell
    ANIMAL & CELL MODELS