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FLASH GENE
Symbol CNNM3 contributors: mct - updated : 28-12-2016
HGNC name cyclin and CBS domain divalent metal cation transport mediator 3
HGNC id 104
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two conserved CBS forming a stable globular domain
  • HOMOLOGY
    interspecies homolog to murine Cnnm3
    Homologene
    FAMILY
  • ACDP family
  • CATEGORY protooncogene , signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • Mg(2+) transporter that is itself pro-oncogenic
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PTP4A2 regulates intracellular magnesium levels by forming a functional heterodimer with the magnesium transporter CNNM3
  • PTP4A2 modulates intracellular Mg(2+) levels and sustains cancer phenotypes by binding to the Mg(2+) transporter CNNM3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS