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FLASH GENE
Symbol CLGN contributors: mct - updated : 19-10-2011
HGNC name calmegin
HGNC id 2060
PROTEIN
PHYSICAL PROPERTIES Hydrophilic Hydrophobic
STRUCTURE
motifs/domains
  • an N-terminal hydrophobic signal peptide
  • two sets of internal repetitive sequences
  • a hydrophilic C terminus with a transmembrane domain and an ER retention signal
  • HOMOLOGY
    interspecies ortholog to murine Clgn
    homolog to rattus Rn.52725
    homolog to Drosophila Cnx99A
    homolog to C.elegans cnx-1
    intraspecies homolog to testis-specific homologs of CANX
    Homologene
    FAMILY calreticulin family
    CATEGORY chaperone/stress , storage
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • type I membrane protein
  • CLGN is membrane-anchored whereas CALR3 is soluble
  • basic FUNCTION
  • testis-specific endoplasmic reticulum chaperone protein playing a role in spermatogeneisis and infertility
  • involved in calcium ion storage
  • having defective zona-binding ability
  • CANX-like lectin chaperone during spermatogenesis and required for the assembly of ADAM (a disintegrin and metalloproteinase) sperm fertilizing proteins ADAM1/ADAM2
  • required for ADAM1A/ADAM2 dimerization and subsequent maturation of ADAM3A
  • testis-specific calreticulin homologs CLGN and CALR3 have distinct but cooperative roles in the maturation of ADAM3A during spermatogenesis and subsequent sperm fertilizing ability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a tissue-specific chaperone complex with the calnexin homologue calmegin (CLGN)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • binding fertilin beta (ADAM2)
  • its expression is regulated by HDAC and CpG methyltransferase in a coordinative way
  • cell & other
    REGULATION
    Other transcriptionally regulated by histone deacetylase (HDAC) and CpG methyltransferase
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for contraception
    reproductionfertility 
    manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for treatment of male infertility
    ANIMAL & CELL MODELS