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FLASH GENE
Symbol CHKA contributors: mct - updated : 20-10-2012
HGNC name choline kinase alpha
HGNC id 1937
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies homolog to murine Chk
homolog to rattus Chka
Homologene
FAMILY
  • choline/ethanolamine kinases family
  • ChoK family of proteins
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalysing the phosphorylation of choline and ethanolamine by ATP
  • may be involved in human carcinogenesis
  • having a regulatory role in phosphatidylcholine pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SRC-dependent link between CHKA and EGFR, which contributes to the regulation of cell proliferation and tumorigenesis
  • cell & other
    REGULATION
    activated by Ras proteins through Ral-GDS and PI3K
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer, colon cancer, lung cancer, prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • disruption of murine Chka leads to embryonic lethality