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FLASH GENE
Symbol KIF16B contributors: mct - updated : 13/10/2008
HGNC name kinesin family member 16B
HGNC id 15869
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • a phox homology (PX) domain
  • a FHA domain
  • a kinesin-motor domain
  • HOMOLOGY
    Homologene
    FAMILY
  • sorting nexin family
  • kinesin-like protein family, kinesin-3 family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    text microtubule associated complex
    basic FUNCTION
  • involved in several stages of intracellular trafficking
  • modulating the intracellular localization of early endosomes and the balance between receptor recycling and degradation
  • acting as a microtubule motor
  • attaches to the membrane of early endosomes, regulates the motility of these organelles, and is required for efficient EGF receptor recycling from early endosomes to cell membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • intracellular signaling cascade
  • microtubule-based movement
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide, other,
  • phosphoinositides
  • ATP
  • protein
  • PTPN21 endosomal localization is mediated by interaction with KIF16B, an endosomal kinesin that modulates receptor recycling at the plasma membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS