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FLASH GENE
Symbol ASB11 contributors: mct - updated : 10-06-2020
HGNC name ankyrin repeat and SOCS box-containing 11
HGNC id 17186
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six ankyrin repeats
  • one SOCS box domain
  • HOMOLOGY
    interspecies ortholog to murine Asb11 (85 pc)
    Homologene
    FAMILY
  • ankyrin repeat
  • SOCS box-containing (ASB) family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in couplage of suppressor of cytokine signaling (SOCS) protein and their partners with elongin B and C
  • is likely a principal regulator of embryonic as well as adult regenerative myogenesis
  • ASB11 is a novel endoplasmic reticulum-associated ubiquitin ligase with the ability to interact and promote the ubiquitination of RPN1, an integral protein of the oligosaccharyltransferase (OST) glycosylation complex
  • CELLULAR PROCESS protein, post translation, targeting
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • JAK kinases
  • activated cytokine receptors
  • elonguin B/C complex
  • expression of ASB11 can increase RPN1 protein turnover (24337577)
  • CUL5-ASB11 is the E3 ligase targeting BIK for ubiquitination and degradation
  • different cellular stresses regulate BIK ubiquitination by ASB11 in opposing directions, which determines whether or not cells survive
  • cell & other
    REGULATION
    induced by cytokines
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS