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FLASH GENE
Symbol CD97 contributors: mct - updated : 20-10-2012
HGNC name CD97 molecule
HGNC id 1711
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • four tandem EGF-like domains
  • two of them with calcium-binding sites
  • a single RGD motif, including several potential N and O glycosylation sites, coupled to a seven-span transmembrane segment (7TM) by a mucin-like spacer domain (site-specific N-glycosylation is an important determinant of (GPCR) proteolytic site proteolysis)
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cd97
    homolog to rattus Rn.7386
    homolog to C.elegans F09A5.2
    Homologene
    FAMILY
  • G-protein coupled receptor 2 family
  • secretin-receptor superfamily
  • EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules
  • CATEGORY adhesion , antigen , receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • acting as a receptor potentially involved in both adhesion and signaling processes early after leucocyte activation
  • shows different features of expression and function in muscle cells compared to hematopoetic and tumor cells
  • is induced in multiple epithelial cancer lineages
  • plays an important role in tumor aggressiveness by binding its cellular ligand CD55
  • CD97 and CD55 both play important roles in tumor dedifferentiation, migration, invasiveness, and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • CD97 heterodimerized and functionally synergized with LPAR1, a GPCR implicated in cancer progression
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • binding to CD95, decay accelerating factor (DAF,CD55)
  • CD97 functioned to mediate invasion in prostate cancer cells, at least in part, by associating with lysophosphatidic acid receptor 1 (LPAR1)
  • CD97, present on peripheral myeloid cells, is a novel interacting partner for THY1 (is an interacting partner for CD97 on activated endothelial cells)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastrointestinal carcinomas
    tumoral     --over  
    in primary gallbladder carcinoma
    constitutional     --over  
    on polymorphonuclear cells (PMNC) of patients with psoriasis
    tumoral     --over  
    of CD97 and its ligand CD55 at the invasion front correlate with rectal tumor recurrence and metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    potential therapeutic cancer target
    ANIMAL & CELL MODELS