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FLASH GENE
Symbol ARL4A contributors: mct/npt/pgu - updated : 03-02-2010
HGNC name ADP-ribosylation factor-like 4A
HGNC id 695
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GTPase domain
  • mono polymer homomer , monomer
    HOMOLOGY
    interspecies ortholog to murine Arl4
    homolog to Drosophila CG2219
    homolog to C.elegans F57H12.1
    Homologene
    FAMILY
  • ARF/ARL GTPase family
  • ADP-ribosylation factors (ARF) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleolus
    text
  • GCC2 and ARL4A localize to the Golgi independently of each other
  • basic FUNCTION
  • having a GTPase activity
  • with ARL4C, and ARL4D, are able to recruit CYTH2 and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form
  • alters the integrity of the Golgi structure by facilitating the interaction of GCC2 with CLASP1 and CLASP2
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • GCC2 acts as a new effector for ARL4A to modulate Golgi organization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS