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FLASH GENE
Symbol AQP10 contributors: mct/npt/pgu - updated : 25-08-2012
HGNC name aquaporin 10
HGNC id 16029
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cytosolic N-terminus
  • six membrane-spanning domain
  • three N-linked glycosylation sequons
  • N-glycosylation signals
  • a C-loop that is the longest of the human aquaporins
  • HOMOLOGY
    interspecies homolog to AQP9
    intraspecies homolog to AQP3,AQP9
    Homologene
    FAMILY
  • aquaglyceroporin family
  • MIP/aquaporin family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • localized on the apical compartment of the intestinal epithelium called the glycocalyx
  • located in the apical membrane of enterocytes and is believed to contribute to the passage of water and glycerol through these intestinal absorptive cells
  • basic FUNCTION
  • aquaglyceroporins, that transport glycerol
  • and small solutes in addition to water
  • may be contribute to water transport in the upper portion of small intestine
  • involvement of a carrier-mediated mechanism in glycerol transport by AQP10
  • uniquely dual functional characteristic of AQP10 as a carrier/channel for solute transport
  • transmembrane facilitator of both water and glycerol transport in the small intestine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS