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FLASH GENE
Symbol ADAM18 contributors: npt/ - updated : 17-09-2004
HGNC name ADAM metallopeptidase domain 18
HGNC id 196
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one EGF-like domain
  • one disintegrin domain
  • a putative integrin-binding glu-cys-asp (ECD) motif
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase family M12B
  • ADAM (a disintegrin and metalloprotease domain) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • sperm surface membrane protein that may be involved in spermatogenesis and fertilization
  • playing a potential role in oocyte recognition
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS