protein
| IFNAR-1 chain of the human type I interferon receptor |
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glucocorticoid receptor |
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c-Fes |
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p300 |
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c-Jun |
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IL-2Rbeta chain |
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p21WAF1/CIP1/SDI1 |
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p94(fer) |
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RPA p32 |
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TSH receptor, TSHR |
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Rac1 GTPase |
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JAK1 and JAK2 |
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NcoA/SRC1a |
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HNF-3 |
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Protein kinase PKR |
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PIAS3 |
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ErbB-2 |
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nuclear factor kappaB (NF-kappaB) p65 and p50 |
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chaperone glucose-regulated protein 58, GRP58 |
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EZI |
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Hsp90 |
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Tip60 |
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GRIM-19 |
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protein inhibitor of activated STAT3, PIAS3 |
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nucleophosmin-anaplastic lymphoma kinase, NPM-ALK |
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STRA13 |
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BRG1 and CDK9 |
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prothymosin-alpha |
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IRAK1 |
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(HIF)-1alpha, CBP/p300 and Ref-1/APE |
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DNMT1 and histone deacetylase 1 |
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Epidermal growth factor receptor, EGFR |
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Daxx |
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RBM8A |
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ARL2BP |
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TRIM28 |
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KAP1 |
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S1P-S1PR1 axis |
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SOX6 |
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STAP2 upregulated PTK6-mediated activation of STAT3 in breast cancer cells |
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may directly mediate EMT(epithelial-mesenchymal transition) progression and regulate ZEB1 expression in colorectal cancer |
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STAT3 plays a key role in SPARC induced G2/M arrest in medulloblastoma cells |
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SIN3A directly interacts with STAT3 and promotes its deacetylation |
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OSM-mediated inhibition of TGFB1-induced CTGF mRNA expression depends on STAT3 |
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GCG induces STAT3 activation in human macrophages |
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Il6/STAT3 modulates estrogen-induced GREB1 transcriptional activity in breast cancer cells |
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STAT1 inhibited VEGFA expression, while STAT3 promoted the expression of VEGFA |
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STAT1 and STAT3 have opposing roles in modulating HIF1A activity and subsequently, VEGFA expression |
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control of HIF1A by STAT1 and STAT3 is an important mechanism by which VEGFA expression is regulated in smooth muscle cells (SMC) |
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unsuspected mechanism of autophagy control that involves STAT3 and EIF2AK2 as interacting partners |
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EGFR, SFKs, and STAT3 can serve as substrates for the protein tyrosine phosphatase TCPTP (PTPN2) |
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TRAF6 is a new STAT3 interactor |
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STAT3 may act as a competitive inhibitor of EIF2AK2 |
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NME1 inhibits STAT3 signaling via a negative feedback mechanism |
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binds directly to the WASF3 promoter and increases transcription levels, which correlates with increased migration potential |
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STAT3 increases expression of BCL6 and enhances recruitment of RNA polymerase II phosphorylated at a site associated with transcriptional initiation, but STAT5B represses BCL6 expression below basal levels and decreases the association of RNA polymerase II at the gene |
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AR-CCL4-STAT3 axis is key regulator during prostate tumor initiation, suggesting important roles of infiltrating macrophages and inflammatory cytokines for the prostate tumorigenesis |
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BTG2 negatively regulated cancer cell growth by inhibiting IL6 expression through downregulation of STAT3 activation |
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in cancer, constitutive activation of STAT3 makes a major contribution to the ability of cancer cells to survive and grow, but the simultaneous upregulation of EGFR and secretion of IL6 can cooperate to desensitize the cancer cells to the actions of negative regulators, especially SOCS3 |
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KLF4 expression resulted from the codependent and synergistic action of NANOG and STAT3 in embryonic stem cells and during initiation of reprogramming |
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UBL4A promotes STAT3 dephosphorylation via mediating the interaction between TC45 (the nuclear isoform of PTPN2) and STAT3 specifically |
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STAT3 binding stabilizes NFKB1 on the UBD promoter and leads to maximum induction of UBD gene expression |
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PTPRT-modulated STAT3 signaling implicated in the regulation of high-fat diet-induced obesity |
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SOX5 and MAF cooperatively induce Th17 cell differentiation via the induction of RORC as downstream targets of STAT3 |
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STAT3 protein regulates vascular smooth muscle cell phenotypic switch by interaction with MYOCD |
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STAT1 and STAT3 have at least partially opposing roles in IL21 signaling in CD4(+) T cells |
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in the intestinal tract, IL22 activates STAT3 to promote intestinal epithelial cell (IEC) homeostasis and tissue healing |
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TNFSF18 could promote Th17 cell differentiation by MAPK14 and STAT3 signaling in autoimmune arthritis |
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BTG2 is regulated by STAT3 signaling and inhibits adipocyte differentiation |
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astrocytic EFNB1 may play an active role in injury-induced synapse remodeling through the activation of STAT3-mediated signaling in astrocytes |
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ARL3 is a novel STAT3-binding partner (ARL3 recognizes the DNA-binding domain as well as the C-terminal region of STAT3, and their binding was the strongest when both proteins were activated |
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SENP3 could thus enhance STAT3 phosphorylation by de-conjugating the SUMO2/3 modification of STAT3 |
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DOCK8 interacts with STAT3 and regulates its activation and the outcome of STAT3-dependent TH17 differentiation |
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genetically linked tumor suppressors SH2D4A and SORBS3 functionally cooperate to inhibit STAT3 signaling in in hepatocellular carcinoma |
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role for CXCL1 and IL8 in CF lung disease severity and identify STAT3 as a modulating pathway |
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anti-viral role for STAT3 in the IFNA1 pathway |
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LOXL3 associates with STAT3 in the nucleus to deacetylate and deacetyliminate STAT3 on multiple acetyl-lysine sites |
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STAT3 and the Ikaros zinc finger transcription factors IKZF3, IKZF1 cooperate to regulate BCL66 expression |
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SMARCA4 and STAT3 coordinately regulate gene clustering and up-regulate GFAP and OSMR transcription |
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ALDH1A2 suppresses epithelial ovarian cancer cell proliferation and migration by downregulating STAT3 |
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STAT3 target METTL8, regulates likely ESC differentiation via JNK signaling |
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STAT3 binds to and activates the promoter of TMUB1, suggesting a putative negative feedback loop between TMUB1 and STAT3 signaling |
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HNF1A regulates hepatic lipid metabolism by promoting the expression of SOCS3 and negatively regulating the STAT3 signaling pathway |
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STAT3 could drive the transcription of NFATC1 by binding to its promoter |
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ZDHHC19 is a palmitoyl acyltransferase that regulates STAT3 |
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SH3GL3 acts as a novel tumor suppressor in glioblastoma tumorigenesis by inhibiting STAT3 signaling |
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STAT3 regulated IFI44L expression and interacted with TET2 which induced DNA demethylation of IFI44L promoter |
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| Stat3 activity was impaired in Stat3beta(-/-) cells | |
Stat3beta-deficient mice exhibit diminished recovery from endotoxic shock and hyperresponsiveness of a subset of endotoxin-inducible genes in liver |
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mice with STAT3 tissue-specific disruption in bone marrow cells during hematopoiesis die within 4-6 weeks after birth with Crohn's disease-like pathogenesis in both the small and large intestine, including segmental inflammatory cell infiltration, ulceration, bowel wall thickening, and granuloma formation |
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mice with cardiac specific deletion of STAT3 are significantly more susceptible to cardiac injury after doxorubicin treatment and develop heart dysfunction with advancing age |
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mice with liver-specific deficiency in STAT-3 show insulin resistance associated with increased hepatic expression of gluconeogenic genes |
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deletion of Stat-3 in mouse respiratory epithelial cells did not alter prenatal lung morphogenesis or postnatal lung function but exposure of adult Stat-3-deleted mice to 95% oxygen caused a more rapidly progressive lung injury associated with alveolar capillary leak and acute respiratory distress |
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epithelial cell injury and inflammatory responses were increased in the Stat-3-deleted mice |
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the epidermis of Stat3-deficient mice showed a significantly reduced proliferative response following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) because of a defect in G1-to-S-phase cell cycle progression and mice were completely resistant to skin tumor development when 12-dimethylbenz[a]anthracene (DMBA) was used as the initiator and TPA as the promoter ( |
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reactive astrocytes in Nes-Stat3(-/-) mice showed limited migration and resulted in markedly widespread infiltration of inflammatory cells, neural disruption and demyelination with severe motor deficits after contusive spinal cord injury |
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selective deletion of Stat3 in DRG neurons of Stat3-floxed mice impairs regeneration of peripheral DRG branches after a nerve cut |
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a sustained activation of the transcription factor signal transducer and activator of STAT3 in ischemic injured and uninjured Pkd1 knockout polycystic kidneys and in human ADPKD kidneys |