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FLASH GENE

Symbol

TUBA1B

contributors: - updated : 31-08-2007

HGNC name	tubulin, alpha 1b
HGNC id	18809

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to Drosohila tub84b
	homolog to C.elegans tba-2
	homolog to rattus T26

intraspecies	paralog to TUBA3
	paralog to TUBA6

Homologene

FAMILY

alpha tubulin gene family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
text	polymerizes to form microtubules

basic FUNCTION

unknown

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	cell structure

PATHWAY

metabolism

signaling

a component	part of a heterodimer polymerizing to form microtubules
	major constituent of microtubules

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP (binding two moles of GTP, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain)

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS