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FLASH GENE
Symbol ZRANB1 contributors: mct/npt - updated : 15-12-2021
HGNC name zinc finger, RAN-binding domain containing 1
HGNC id 18224
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal ankyrin-repeat Ub-binding domain is required for Lys29 and Lys33 linkage specificity
  • an ankyrin-repeat ubiquitin-binding domain determines ZRANB1 specificity for atypical ubiquitin chains
  • three RANBP2-type zinc fingers (three tandem NZF motifs)
  • one OTU domain
  • HOMOLOGY
    interspecies homolog to murine Zranb1 (99 pc)
    intraspecies homolog to A20
    Homologene
    FAMILY
  • peptidase C64 family
  • OTU domain deubiquitinase family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • modulating TNF alpha signaling
  • may have a function in stem cell self-renewal or differentiation (Tran 2008)
  • specifically hydrolyzes both Lys29- and Lys33-linked diubiquitin
  • is an innate immunological regulator of inflammatory T cell responses
  • is a previously unrecognized inhibitor of hepatocellular carcinoma progression and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with TRAF6
  • can bind to and deubiquitylate the APC tumor suppressor protein, a negative regulator of Wnt-mediated transcription (Tran 2008)
  • ZRANB1 is the EZH2 deubiquitinase, and binds, deubiquitinates, and stabilizes EZH2
  • E3 ubiquitin ligase HECTD1 is a substrate of ZRANB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlated with poorer survival in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is a new candidate prognostic biomarker for HCC treatment
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    therapeutic potential for targeting ZRANB1 in breast cancer
    ANIMAL & CELL MODELS