basic FUNCTION
| playing a role in the regulation of blood pressure through inactivation of angiotensin 2 and/or generation of bradykinin in the kidney |
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NUCB2/ERAP1 complexes, which associate with TNFRSF1A play an important role in mediating TNFRSF1A release to the extracellular compartment |
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a multifunctional aminopeptidase that may modulate inflammatory events by promoting IL6Ralpha and TNFR1 shedding |
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IFN-gamma-induced aminopeptidase that trims longer precursors to the antigenic peptides presented on MHC class I molecules to facilitates antigen presentation |
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major enzyme that trims precursor peptides in the endoplasmic reticulum and, in this process, can generate or destroy antigenic peptides (trims MHC class I-presented peptides and plays an important role in immunodominance) |
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having function in the cleavage of cell-surface cytokine receptors (e.g. TNFR1) and peptide binding to MHC class I molecules in the ER |
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play a role in blood pressure regulation and essential hypertension in addition to innate immune and inflammatory responses |
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ERAP1, ERAP2, LNPEP play critical roles in the generation of antigenic peptides |
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trims antigen precursors to fit into MHC class I proteins, through a generic aminopeptidase structure adapted for the specialized function of trimming antigenic precursors |
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endoplasmic reticulum aminopeptidase involved in peptide trimming before HLA class I presentation |
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ERAP1 and ERAP2 cooperate to trim antigenic peptide precursors for loading onto MHC class I molecules and help regulate the adaptive immune response |
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ERAP1 and ERAP2 might play an important role in shaping the MHC class I-presented peptide repertoire |
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ERAP1 and ERAP2 are two multifunctional enzymes playing an important role in the biological processes requiring trimming of substrates, including the generation of major histocompatibility complex (MHC) class I binding peptide |