basic FUNCTION
| playing a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation |
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acts to control the cross-talk between integrin-induced and TNFalpha-induced signaling pathways, inhibiting the former and stimulating the latter, thereby inhibiting proliferation and survival and promoting the apoptosis of cancer cells (Tamura 2006) |
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playing an important role in inhibiting oncogenic transformation |
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function as tumor suppressor protein, and important physiological regulator of cell growth and of cellular stress signaling (Lammers 2007) |
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plays key roles in a variety of cell functions, including cell proliferation, adhesion and migration (Nakrieko 2008) |
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with XPO1, are pivotal modulators of ILK subcellular distribution and activity in the keratinocytes (Nakrieko 2008) |