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FLASH GENE
Symbol ILKAP contributors: mct/npt/shn - updated : 24-09-2012
HGNC name integrin-linked kinase-associated serine/threonine phosphatase
HGNC id 15566
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to Ilkap, Mus musculus
ortholog to Ilkap, Rattus norvegicus
ortholog to ILKAP, Pan troglodytes
Homologene
FAMILY
  • protein phosphatase (PP2C) family
  • CATEGORY adhesion , enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation
  • acts to control the cross-talk between integrin-induced and TNFalpha-induced signaling pathways, inhibiting the former and stimulating the latter, thereby inhibiting proliferation and survival and promoting the apoptosis of cancer cells (Tamura 2006)
  • playing an important role in inhibiting oncogenic transformation
  • function as tumor suppressor protein, and important physiological regulator of cell growth and of cellular stress signaling (Lammers 2007)
  • plays key roles in a variety of cell functions, including cell proliferation, adhesion and migration (Nakrieko 2008)
  • with XPO1, are pivotal modulators of ILK subcellular distribution and activity in the keratinocytes (Nakrieko 2008)
  • CELLULAR PROCESS cell cycle, progression
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • magnesium Mg2+
  • manganese Mn2+
  • protein
  • integrin-linked kinase 1, ILK1
  • PALLD
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS