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FLASH GENE
Symbol FAM3C contributors: SGE/npt - updated : 10-09-2009
HGNC name family with sequence similarity 3, member C
HGNC id 18664
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GG domain
  • a hydrophobic leader sequence
  • an N-terminal signal peptide
  • 4-helix bundle
  • HOMOLOGY
    interspecies ortholog to fam3c, Danio rerio
    ortholog to Fam3c, Mus musculus
    ortholog to Fam3c, Rattus norvegicus
    homolog to LOC463680, Pan troglodytes
    intraspecies homolog to FAM3A
    Homologene
    FAMILY
  • FAM3 family
  • CATEGORY secretory , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • FAM3C is a tumor- and metastasis-inducing protein cooperates with oncogenic Ras to cause and maintain TGF-b-independent epithelial to mesenchymal transition (EMT) of hepatocyte (Lahsnig et al 2009)
  • collaboration of FAM3C with oncogenic Ras enhances tumor formation, nuclear accumulation of b-catenin and Stat3 tyrosine phosphorylation (Lahsnig et al 2009)
  • play a role in the EMT regulation
  • may be involved in retinal laminar formation processes (Katahira 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cooperates with oncogenic Ras
  • ILEI stimulates upregulation of PDGF-C/PDGF-Rb and enhances proliferation and migration in oncogenic Ras-expressing MIM-R-GFP hepatocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS