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FLASH GENE
Symbol EAF1 contributors: mct/npt/pgu - updated : 15-02-2010
HGNC name ELL associated factor 1
HGNC id 20907
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an activation domain homologous with the AF4/FMR2 family
  • HOMOLOGY
    Homologene
    FAMILY
  • EAF family
  • ELL family transcription factors
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • strong positive regulator of ELL elongation activity
  • playing a role in regulation of RNA polymerase II transcription
  • shows structural similarities with EP400/Domino, a subunit of the NuA4-related TIP60 complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of Cajal bodies
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with RNA polymerase 2 transcriptional elongation factors
  • interacting with TFPT (TFPT is an important binding partner and a functional regulator of U19/EAF2, EAF1, and/or ELL)
  • MED26 can recruit EAF1 or EAF1-associated complexes to immobilized promoters via direct interaction of the MED26 NTD with EAF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS