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FLASH GENE
Symbol SFN contributors: mct/npt/pgu - updated : 26-06-2012
HGNC name stratifin
HGNC id 10773
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Mkrn3
Homologene
FAMILY
  • 14.3.3 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be involved in negative regulation of protein kinase activity, cell proliferation, signal transduction, regulation of cell cycle
  • implicated in G2/M cell cycle arrest by Tp53 (Kuroda 2007)
  • acts as a tumor suppressor and is often inactivated during tumor development
  • having function linked to epidermal stratification and differentiation in the skin (Xin 2010)
  • critical for regulating corneal epithelial proliferation and differentiation by regulating Notch signaling activity (Xin 2010)
  • important G2M cell cycle checkpoint regulator and its expression is induced by DNA damage stress through a TP53-dependent pathway (Xin 2010)
  • regulates corneal epithelial cell proliferation and differentiation by maintaining Notch activity (Xin 2010)
  • plays a critical role in retaining epithelial polarity, through its interaction with PARD3 (Ling 2010)
  • plays a critical role in retaining epithelial polarity
  • regulates cytokinesis and cell cycle arrest induced by DNA damage
  • maintains FOXO1 at a consistent level critical for normal B-cell antigen receptor signaling and B-cell survival
  • its levels are critical for maintaining TP53 activity in response to DNA damage and regulating signal mediators such as AKT1
  • TP63 and SFN play opposing roles in the development of skin tumors and the accumulation of TP63 is essential for Ras/SFN mutation-induced papilloma formation and squamous cell carcinoma carcinogenesis
  • intracellular, phosphoserine binding protein, playing a regulatory role in epidermal epithelial differentiation
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IRF6 for the keratinocyte proliferation-differentiation switch
  • target of CA11 (for degradation, leading to MDM2 stabilization)
  • binds to p37 AUF1, retains it in the cytoplasm probably by masking its NLS, and enhances rapid turnover of ARE (AU-rich destabilizing element)-mRNAs
  • targets RFWD2 for nuclear export, thereby preventing RFWD2-mediated TP53 nuclear export
  • LRFN4 complexed with SFN and NCK1 to mediate elongation in monocytic cells via RAC-1-mediated actin cytoskeleton reorganization
  • cell & other
    REGULATION
    induced by TP53 in response to DNA damage
    Other COPS6 associates with RFWD2 and is involved in SFN ubiquitin-mediated degradation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in mammary carcinoma by hypermethylation and invulval squamous neoplasia
    tumoral     --low  
    in prostate cancer
    tumoral     --low  
    involved in the uncontrolled cell cycle in intrahepatic cholangiocarcinoma and is a significant indicator of poor prognosis for patients with intrahepatic cholangiocarcinoma
    tumoral     --over  
    in gastric cancer, significantly correlated with clinical stage and tumor invasion
    tumoral     --over  
    hypomethylation of the promoter leads to increased expression in non-small cell lung cancer
    tumoral        
    epigenetic silencing of 14-3-3sigma might contribute to tumor progression in malignant melanoma via loss of cell cycle control, impaired cellular senescence program
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    therapeutic molecular target for gastric cancer
    ANIMAL & CELL MODELS