protein
| interacts with chromatin-bound cohesin and functions during the establishment or maintenance of cohesion in S or G2 phase, respectively |
|
interacting with SGOL1 |
|
interaction of sororin with cohesin, either directly or indirectly, is potentially important for function |
|
stepwise loss of cohesion between chromosome arms and centromeres is caused by local regulation of WAPL activity, which is controlled by the phosphorylation state of CDCA5 |
|
in addition to recruiting PPP2CA to dephosphorylate cohesin and CDCA5, SGO1 physically shields cohesin from WAPL |
|
SMC3 acetylation leads to recruitment of CDCA5, inhibition of WAPL, and stabilization of cohesin on DNA |
|
CACTIN is essential for efficient splicing of thousands of pre-mRNAs, and incomplete splicing of the pre-mRNA of sororin (also known as CDCA5), a cohesin-associated factor, is largely responsible for the aberrant chromatid separation in cactin-depleted cells |
|
CDCA5 could be a direct mRNA target of SNRPD2, SNRPD3 and NHP2L1 |