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FLASH GENE
Symbol CDCA5 contributors: mct - updated : 03-09-2016
HGNC name cell division cycle associated 5
HGNC id 14626
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a KEN box for APC-dependent ubiquitination
  • highly conserved motif at the C terminus interacting with the cohesin complex is critical to its ability to mediate sister chromatid cohesion
  • HOMOLOGY
    interspecies homolog to Drosophila CG13890
    homolog to C.elegans R06F6.9
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase
  • regulates the ability of the cohesin complex to mediate sister chromatid cohesion, perhaps by altering the nature of the interaction of cohesin with the chromosomes
  • implicated in promoting cohesion through effects on cohesin complexes, and is involved in maintenance of cohesion in response to the spindle checkpoint
  • sororin (CDCA5) and Shugoshin (SGOL1) protect centromeric cohesion in response to the spindle checkpoint, but prevent the removal of cohesion by a mechanism independent of the APC/C
  • required for the increased stability of the cohesin complex on chromatin following DNA replication and sister chromatid cohesion during G2
  • associates with the cohesin complex and regulates the segregation of sister chromatids
  • cohesin dynamics are controlled by the releasing factors PDS5B and WAPL and the cohesin stabilizer CDCA5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with chromatin-bound cohesin and functions during the establishment or maintenance of cohesion in S or G2 phase, respectively
  • interacting with SGOL1
  • interaction of sororin with cohesin, either directly or indirectly, is potentially important for function
  • stepwise loss of cohesion between chromosome arms and centromeres is caused by local regulation of WAPL activity, which is controlled by the phosphorylation state of CDCA5
  • in addition to recruiting PPP2CA to dephosphorylate cohesin and CDCA5, SGO1 physically shields cohesin from WAPL
  • SMC3 acetylation leads to recruitment of CDCA5, inhibition of WAPL, and stabilization of cohesin on DNA
  • CACTIN is essential for efficient splicing of thousands of pre-mRNAs, and incomplete splicing of the pre-mRNA of sororin (also known as CDCA5), a cohesin-associated factor, is largely responsible for the aberrant chromatid separation in cactin-depleted cells
  • CDCA5 could be a direct mRNA target of SNRPD2, SNRPD3 and NHP2L1
  • cell & other
    REGULATION
    Other regulation by CDK1-mediated phosphorylation, and its phosphorylation causes its release from chromatin in mitosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in the majority of lung cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    suppression of the ERK-CDCA5 pathway could be a promising strategy for cancer therapy
    ANIMAL & CELL MODELS