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FLASH GENE
Symbol NUF2 contributors: mct/npt - updated : 01/10/2008
HGNC name NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
HGNC id 14621
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Cdca1 (79.2 pc)
homolog to murine Nuf2 (73.2 pc)
Homologene
FAMILY
  • NUF2 family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localized to kinetochores from late prophase to anaphase
  • localized specifically to the outer plate of the kinetochore
  • basic FUNCTION
  • acting at the centromere to establish a connection with the spindle for proper chromosome segregation
  • required for the spindle checkpoint
  • kinetochore component conserved from yeast to humans, is essential for proper chromosome alignment and segregation during mitosis (Wei 2006)
  • required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore
  • having a necessary role for correct binding of spindle checkpoint proteins to kinetochore (act independent of each other in kinetochore assembly, but their combined activities are required for checkpoint signaling)
  • kinetochore component conserved from yeast to humans, is essential for proper chromosome alignment and segregation during mitosis (Wei 2006)
  • directly connects kinetochores to spindle microtubules (Wilson-Kubalek 2008)
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a conserved protein complex associated with the centromere
  • component of the essential kinetochore- associated NDC80 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CENPH (for kinetochore assembly)
  • cell & other
    REGULATION
    Other can be phosphorylated by AURKA and AURKB
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung cancer
    tumoral     --over  
    in colorectal and gastric cancers (Kaneko 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target suppression of NUF2 or NDC80 activity and/or inhibition of the NUF2-NDC80 complex formation could be a promising therapeutic target for treatment of lung cancers
    ANIMAL & CELL MODELS