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FLASH GENE
Symbol CDC14B contributors: mct - updated : 15-02-2012
HGNC name CDC14 cell division cycle 14 homolog B (S. cerevisiae)
HGNC id 1719
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
contains a protein-tyrosine phosphatase domain
HOMOLOGY
interspecies ortholog to yeast S.cerevisiae Cdc14
homolog to Drosophila CG7134
homolog to C.elegans C17G10.4c
intraspecies homolog to CDC14A
Homologene
FAMILY dual specificity protein tyrosine phosphatase family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,nucleus,nucleoplasm
intracellular,nucleus,nucleolus
text
  • in response to genotoxic stress in G2, the phosphatase, translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase FZR1, with the consequent degradation of PLK1, a prominent mitotic kinase
  • a fraction of CDC14B associates with centrosomes
  • basic FUNCTION
  • involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control
  • potential function in maintaining the fidelity of centrosome duplication cycle
  • has a central function in the G2 DNA damage checkpoint, and is potentially required for efficient DNA repair
  • serves a critical role in regulating progression through mitosis, which is distinct from CDC14A
  • CDC14B-dependent modulation of CDC25C phosphatase and CDK1 activity is tightly linked to correct chromosome segregation and bipolar spindle formation, processes that are required for proper progression through mitosis and maintenance of genomic stability
  • disrupting the cytoskeletal F-actin organization with loss of actin stress fibers and vinculin adhesions in a phosphatase-dependent manner
  • phosphatase displaying oncogenic activity mediated by the Ras-Mek signaling pathway
  • redundancy between CDC14B and CDC14A in DNA Double-Strand Break Repair repair
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, progression
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to TP53
  • CHEK1 substrate (interplay between CHEK1 kinase and CDC14B phosphatase involving radiation-induced nucleolar shuttling to facilitate error-free cell cycle progression and prevent genomic instability)
  • CDH1 is a downstream target of CDC14B in DSB repair
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS