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FLASH GENE
Symbol LTA4H contributors: - updated : 28-02-2006
HGNC name leukotriene A4 hydrolase
HGNC id 6710
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
  • hydrolyzing an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to myocardial infarction
    Variant & Polymorphism SNP haplotype HapK correlated with risk of myocardial infarction and increased LTB4 in Africans Americans
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS