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FLASH GENE
Symbol CBX4 contributors: mct/npt/pgu - updated : 08-07-2015
HGNC name chromobox homolog 4 (Pc class homolog, Drosophila)
HGNC id 1554
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a chromo (CHRromatin Organization MOdifier) domain, conserved and chromobox regions that were dispensable for chromatin association
  • HOMOLOGY
    interspecies homolog to Drosophila polycomb
    homolog to murine Cbx4
    Homologene
    FAMILY
  • polycomb group proteins family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in maintaining the transcriptionally repressive state of genes, modifies chromatin, rendering it heritably changed in its expressibility
  • repressor of proto-oncogenes
  • negative regulation of homeotic gene (Polycomb group)
  • functioning as a SUMO E3 ligase for DNMT3A and it might be involved in the functional regulation of DNA methyltransferases by promoting their SUMO modification
  • functions as a transcriptional suppressor, and is a candidate of FHL1-binding proteins
  • having ability to recruit both CTBP1 and UBE2I to polycomb group bodies
  • acting as a transcriptional co-repressor (
  • maintains human epidermal stem cells as slow-cycling and undifferentiated, while protecting them from senescence
  • inhibits stem cell activation and differentiation through its SUMO ligase activity
  • has an essential and non-redundant role in thymic organogenesis
  • is a crucial regulator for the generation and maintenance of the thymic epithelium and, hence, for thymocyte development
  • CELLULAR PROCESS cell life, antiapoptosis
    nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text osteosarcoma cells
    PATHWAY
    metabolism
    signaling
    a component
  • component of the chromatin-associated polycomb complex (PCG)
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to CBX2
  • interacting with DNMT3B
  • KDM5B interacting with CBX4 (C-terminal region, including the COOH box, was required for the interaction with the N-terminus of KDM5B) (
  • might coordinate multiple enzymatic activities to regulate CTBP1 function
  • CBX4 physically interacts and functionally correlates with TP63, which is a transcriptional regulator that is proposed to be important for the maintenance of the stemness of epithelial progenitors
  • plays a critical role in tumor angiogenesis by governing HIF1A protein
  • NDN necdin, MAGED1, MAGEF1 and MAGEL2 bound to PIAS1 but not to NSMCE2 or CBX4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS