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FLASH GENE
Symbol NECTIN2 contributors: mct - updated : 20-12-2016
HGNC name nectin cell adhesion molecule 2
HGNC id 9707
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 2 Ig-like C2-type (immunoglobulin-like) domains
  • a Ig-like V-type (immunoglobulin-like) domain
  • extracellular domains are composed of an N-terminal variable-type Ig (IgV) domain, followed by two constant-type Ig (IgC) domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Mph gene
    Homologene
    FAMILY
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • Herpes virus entry mediator B
  • Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells
  • expressed on normal cells of an epithelial origin, such as endothelial cells (Stanietsky 2009)
  • mediate cell–cell adhesion through homophilic and heterophilic interactions
  • CDH5, NECTIN2, and CLDN5 are involved in the regulation of vascular permeability in a mutually interacting manner, which indicates their prominent role for the functionality of the human corpus luteum
  • NECTIN1, NECTIN2, NECTIN3, NECTIN4 are involved in the formation of functioning adherence and tight junctions
  • accumulation of a soluble form of NECTIN2 is required for exerting the resistance against herpes simplex virus type 2 (HSV-2) infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of TIGIT with PVR and NECTIN2 inhibits human NK cell cytotoxicity
  • cytoplasmic tails of the nectins bind the F-actin–binding protein afadin and support connections with the actin cytoskeleton similar to those observed in the cadherin and integrin systems
  • ZYX–NECTIN2 interaction plays a critical role in zyxin targeting to these sites
  • TIGIT is a novel inhibitory receptor, interacting with two ligands: PVR and NECTIN2 and to inhibit human NK-cell cytotoxicity
  • NECTIN3 trans-interacts with NECTIN2 to promote lymphocyte and monocyte extravasation
  • TIGIT, upon interaction with either of its two ligands, NECTIN2 or poliovirus receptor (PVR), inhibits activation of T and NK cells
  • interaction of NECTIN2 with CDH2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • putative susceptibility factor for Alzheimer's disease
  • nonsyndromic cleft lip with or without cleft palate
  • Variant & Polymorphism
  • G allele showed a significant elevated risk for nonsyndromic cleft lip with or without cleft palate
  • Candidate gene
    Marker
  • prognostic role of NECTIN2 in non-metastatic colorectal cancer
  • Therapy target
    ANIMAL & CELL MODELS
  • homozygous deletion of either Nectin2 or Nectin3 leads to male-specific infertility in mice