basic FUNCTION
| Herpes virus entry mediator B |
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Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells |
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expressed on normal cells of an epithelial origin, such as endothelial cells (Stanietsky 2009) |
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mediate cell–cell adhesion through homophilic and heterophilic interactions |
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CDH5, NECTIN2, and CLDN5 are involved in the regulation of vascular permeability in a mutually interacting manner, which indicates their prominent role for the functionality of the human corpus luteum |
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NECTIN1, NECTIN2, NECTIN3, NECTIN4 are involved in the formation of functioning adherence and tight junctions |
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accumulation of a soluble form of NECTIN2 is required for exerting the resistance against herpes simplex virus type 2 (HSV-2) infection |